Dihydroberberine is a botanical extract derived from Reduction product of berberine, standardized to Dihydroberberine (pure). With CAS registry number 483-15-8, this ingredient belongs to the Metabolism & Lipid Regulators category of weight management actives. DHB is reduced berberine with ~5× higher oral absorption. After absorption, oxidized back to berberine → same AMPK activation, fat oxidation, insulin sensitivity improvement. Same compound at target tissues, better delivery. As a B2B manufacturer, Shaanxi Baisifu Biological Engineering Co., Ltd. supplies Dihydroberberine in bulk quantities with full Certificate of Analysis (COA), ensuring consistent Dihydroberberine (pure) content and regulatory compliance for dietary supplement, functional food, and nutraceutical applications.
Standard specifications for Dihydroberberine bulk supply from Baisifu:
DHB is reduced berberine with ~5× higher oral absorption. After absorption, oxidized back to berberine → same AMPK activation, fat oxidation, insulin sensitivity improvement. Same compound at target tissues, better delivery.
Level II. Turner et al. (2021) showed DHB at 1/5 berberine dose produces equivalent AMPK activation. Human data emerging. Bioavailability advantage well-documented.
Same safety profile as berberine, potentially fewer GI side effects due to lower dosing. CYP3A4 inhibition persists. Not for pregnant/lactating women.
Shaanxi Baisifu Biological Engineering Co., Ltd. manufactures and supplies Dihydroberberine (CAS 483-15-8) in bulk quantities for: • Dietary supplement manufacturers (capsules, softgels, tablets, powders)
• Functional food & beverage producers
• Nutraceutical brands seeking Dihydroberberine (pure) standardized ingredient
• Cosmetics companies (anti-cellulite, metabolic support topical) Each batch includes full Certificate of Analysis (COA) with:
• Dihydroberberine (pure) content verification (HPLC/UV)
• Heavy metals, microbial, moisture compliance
• Pesticide residue testing (where applicable)
• Stability data and shelf life confirmation Available forms: powder extract, oil-based softgel fill, microencapsulated powder
Minimum order: 1 kg (sample quantities available)
Lead time: 7–15 business days
Packaging: 25 kg/drum, double-layer PE bag + fiber drum, nitrogen flush available
Q1: Advantage over Berberine?
~5× higher oral bioavailability. Achieves equivalent AMPK activation at 1/5 dose (100-150 mg DHB vs. 500 mg berberine). Lower GI side effects, lower cost per effective dose.
Q2: Is DHB a different compound?
Reduced derivative of berberine (2 extra hydrogen atoms for better membrane permeability). In body, oxidized back to berberine. Optimized delivery form, not different drug.
For complementary weight management formulations, consider combining Dihydroberberine with: Berberine, Resveratrol, Green Tea Extract, Curcumin. Multi-ingredient stacks targeting different mechanisms (lipase inhibition, AMPK activation, thermogenesis, appetite suppression) produce synergistic effects superior to single-ingredient products.
About Baisifu: Shaanxi Baisifu Biological Engineering Co., Ltd. (No.69, Jinye Road, Xi'an, 710065, Shaanxi, China | Tel: 0086-29-81110978) is a GMP/ISO-certified manufacturer of botanical extracts, food flavors, amino acids, peptides, and biopesticides with 1,000+ products exported to US/EU B2B markets.
Disclaimer: This content is for informational and B2B product development purposes only. Dihydroberberine (CAS 483-15-8) is a raw ingredient for dietary supplement and functional food formulation, not a finished consumer product. Claims cited are from published research and regulatory approvals — they do not constitute medical advice or guarantee specific outcomes. Consult regulatory experts for target market compliance.
| Parameter | Specification |
|---|---|
| Dihydroberberine | ≥97% |
| Appearance | Yellow to pale yellow powder |
| Solubility | Better water solubility than berberine |
| Particle Size | 80 mesh |
| Moisture | ≤2% |
| Heavy Metals | ≤10 ppm |
| Assay | 97-103% |
| Bioavailability | ~5× berberine |
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