/ Berberine is a botanical extract derived from Coptis chinensis / Phellodendron amurense / Berberis vulgaris, standardized to Berberine (pure). With CAS registry number 2086-83-1, this ingredient belongs to the Metabolism & Lipid Regulators category of weight management actives. Berberine inhibits mitochondrial complex I → mild ATP reduction → AMPK activation (same pathway as exercise/metformin). AMPK → fat oxidation, ACC inhibition (blocks fatty acid synthesis), GLUT4 translocation (insulin sensitivity), downregulates SREBP-1c/FAS. Also modulates gut microbiota (increases Akkermansia muciniphila). "Natural metformin." As a B2B manufacturer, Shaanxi Baisifu Biological Engineering Co., Ltd. supplies Berberine in bulk quantities with full Certificate of Analysis (COA), ensuring consistent Berberine (pure) content and regulatory compliance for dietary supplement, functional food, and nutraceutical applications.
Standard specifications for Berberine bulk supply from Baisifu:
Berberine inhibits mitochondrial complex I → mild ATP reduction → AMPK activation (same pathway as exercise/metformin). AMPK → fat oxidation, ACC inhibition (blocks fatty acid synthesis), GLUT4 translocation (insulin sensitivity), downregulates SREBP-1c/FAS. Also modulates gut microbiota (increases Akkermansia muciniphila). "Natural metformin."
Level I for metabolic effects. Yin et al. (2008) showed berberine = metformin for glucose lowering. Multiple studies: 2-4 kg reduction over 3 months.
Generally safe at 500 mg 2-3× daily. GI discomfort ~10%. ⚠Inhibits CYP3A4 → may increase blood levels of co-administered drugs (statins, etc.). Professional supervision with prescription meds. Not for pregnant women.
Shaanxi Baisifu Biological Engineering Co., Ltd. manufactures and supplies Berberine (CAS 2086-83-1) in bulk quantities for: • Dietary supplement manufacturers (capsules, softgels, tablets, powders)
• Functional food & beverage producers
• Nutraceutical brands seeking Berberine (pure) standardized ingredient
• Cosmetics companies (anti-cellulite, metabolic support topical) Each batch includes full Certificate of Analysis (COA) with:
• Berberine (pure) content verification (HPLC/UV)
• Heavy metals, microbial, moisture compliance
• Pesticide residue testing (where applicable)
• Stability data and shelf life confirmation Available forms: powder extract, oil-based softgel fill, microencapsulated powder
Minimum order: 1 kg (sample quantities available)
Lead time: 7–15 business days
Packaging: 25 kg/drum, double-layer PE bag + fiber drum, nitrogen flush available
Q1: Is Berberine as effective as metformin?
Yin et al. (2008) showed equivalent glucose-lowering at same dosage. Different AMPK activation mechanism. Additional benefits: gut microbiota modulation, lipid-lowering. Sold as supplement (not FDA-approved drug).
Q2: Why is Dihydroberberine popular?
~5× higher bioavailability. Berberine has <1% absorption. DHB converts to berberine in body, same AMPK activation at 1/5 dose. More cost-effective per effective dose.
Q3: Can combine with other weight-loss extracts?
Yes — with green tea (AMPK+fat oxidation), resveratrol (SIRT1+AMPK), lotus leaf (lipase+AMPK). Avoid CYP3A4-metabolized drugs.
For complementary weight management formulations, consider combining Berberine with: Dihydroberberine, Resveratrol, Green Tea Extract, Curcumin. Multi-ingredient stacks targeting different mechanisms (lipase inhibition, AMPK activation, thermogenesis, appetite suppression) produce synergistic effects superior to single-ingredient products.
About Baisifu: Shaanxi Baisifu Biological Engineering Co., Ltd. (No.69, Jinye Road, Xi'an, 710065, Shaanxi, China | Tel: 0086-29-81110978) is a GMP/ISO-certified manufacturer of botanical extracts, food flavors, amino acids, peptides, and biopesticides with 1,000+ products exported to US/EU B2B markets.
Disclaimer: This content is for informational and B2B product development purposes only. Berberine (CAS 2086-83-1) is a raw ingredient for dietary supplement and functional food formulation, not a finished consumer product. Claims cited are from published research and regulatory approvals — they do not constitute medical advice or guarantee specific outcomes. Consult regulatory experts for target market compliance.
| Parameter | Specification |
|---|---|
| Berberine | ≥97% |
| Appearance | Yellow crystalline powder |
| Solubility | Partially water/ethanol-soluble |
| Particle Size | 80 mesh |
| Moisture | ≤2% |
| Heavy Metals | ≤10 ppm |
| Assay | 97-103% |
| Melting Point | 145°C |
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