Conjugated Linoleic Acid (CLA)

Conjugated Linoleic Acid (CLA) — CAS 121250-47-3 | Bulk Supplier & Manufacturer

What is Conjugated Linoleic Acid (CLA)?

CLA (Conjugated Linoleic Acid (CLA)) is a botanical extract derived from Safflower oil isomerization, standardized to CLA mixed isomers. With CAS registry number 121250-47-3, this ingredient belongs to the Metabolism & Lipid Regulators category of weight management actives. CLA (t10,c12 isomer) modulates PPARγ — master transcription factor for adipocyte differentiation. Downregulates PPARγ → inhibits pre-adipocyte maturation, promotes adipocyte apoptosis, enhances fatty acid oxidation in muscle, preserves lean mass. "Body recomposition" positioning. As a B2B manufacturer, Shaanxi Baisifu Biological Engineering Co., Ltd. supplies Conjugated Linoleic Acid (CLA) in bulk quantities with full Certificate of Analysis (COA), ensuring consistent CLA mixed isomers content and regulatory compliance for dietary supplement, functional food, and nutraceutical applications.

Conjugated Linoleic Acid (CLA) Specifications

Standard specifications for Conjugated Linoleic Acid (CLA) bulk supply from Baisifu:

How Conjugated Linoleic Acid (CLA) Works for Weight Loss

CLA (t10,c12 isomer) modulates PPARγ — master transcription factor for adipocyte differentiation. Downregulates PPARγ → inhibits pre-adipocyte maturation, promotes adipocyte apoptosis, enhances fatty acid oxidation in muscle, preserves lean mass. "Body recomposition" positioning.

Conjugated Linoleic Acid (CLA) Clinical Evidence & Research

Level II. Meta-analyses show 0.5-1.5 kg additional fat loss at 3.2 g/day for ≥12 weeks. Preferential fat% reduction rather than total weight loss. Best for body recomposition.

Conjugated Linoleic Acid (CLA) Applications & Usage

• Softgel supplements (CLA 80%)
• Sports nutrition (body recomposition)
• Fortified dairy products
• Weight maintenance formulas
• Meal replacement shakes

Conjugated Linoleic Acid (CLA) Safety & Regulatory Status

EFSA ≤3 g/day. Long-term >6 months at >4 g/day may increase insulin resistance and CRP (inflammatory marker). t10,c12 isomer responsible for insulin risk. GI discomfort common initially.

Conjugated Linoleic Acid (CLA) — B2B Bulk Supply from Baisifu

Shaanxi Baisifu Biological Engineering Co., Ltd. manufactures and supplies Conjugated Linoleic Acid (CLA) (CAS 121250-47-3) in bulk quantities for: • Dietary supplement manufacturers (capsules, softgels, tablets, powders)
• Functional food & beverage producers
• Nutraceutical brands seeking CLA mixed isomers standardized ingredient
• Cosmetics companies (anti-cellulite, metabolic support topical) Each batch includes full Certificate of Analysis (COA) with:
• CLA mixed isomers content verification (HPLC/UV)
• Heavy metals, microbial, moisture compliance
• Pesticide residue testing (where applicable)
• Stability data and shelf life confirmation Available forms: powder extract, oil-based softgel fill, microencapsulated powder
Minimum order: 1 kg (sample quantities available)
Lead time: 7–15 business days
Packaging: 25 kg/drum, double-layer PE bag + fiber drum, nitrogen flush available

Conjugated Linoleic Acid (CLA) — Frequently Asked Questions

Q1: Does CLA really work?

Modest but consistent 0.5-1.5 kg fat loss over 12 weeks at 3.2 g/day. Effect on body composition (fat% reduction) rather than dramatic weight loss. Best for fitness consumers wanting fat loss+muscle retention.

Q2: Optimal dosage?

3.2 g/day minimum effective dose. ≥12 weeks continuous use required. 2-3 softgels/day delivering 3.2-6.4 g total CLA is standard.

Q3: Suitable for vegetarians?

CLA from safflower oil is plant-based, but most sold in gelatin softgels. Vegetarian softgel alternatives available.

Related Weight-Loss Extracts

For complementary weight management formulations, consider combining Conjugated Linoleic Acid (CLA) with: L-Carnitine, Green Tea Extract, Quercetin, Curcumin. Multi-ingredient stacks targeting different mechanisms (lipase inhibition, AMPK activation, thermogenesis, appetite suppression) produce synergistic effects superior to single-ingredient products.

About Baisifu: Shaanxi Baisifu Biological Engineering Co., Ltd. (No.69, Jinye Road, Xi'an, 710065, Shaanxi, China | Tel: 0086-29-81110978) is a GMP/ISO-certified manufacturer of botanical extracts, food flavors, amino acids, peptides, and biopesticides with 1,000+ products exported to US/EU B2B markets.

Disclaimer: This content is for informational and B2B product development purposes only. Conjugated Linoleic Acid (CLA) (CAS 121250-47-3) is a raw ingredient for dietary supplement and functional food formulation, not a finished consumer product. Claims cited are from published research and regulatory approvals — they do not constitute medical advice or guarantee specific outcomes. Consult regulatory experts for target market compliance.