Yohimbine HCl is a botanical extract derived from Pausinystalia yohimbe bark (West African), standardized to Yohimbine HCl. With CAS registry number 4142-48-3, this ingredient belongs to the Fat Oxidation & Thermogenesis category of weight management actives. Yohimbine is a selective α-2 adrenergic antagonist. α-2 receptors suppress lipolysis when activated ("anti-lipolytic"). By blocking α-2, yohimbine removes this suppression, allowing catecholamines to freely stimulate β-receptors for lipolysis. Particularly effective for "stubborn fat" (lower abs, hips, thighs) where α-2 density is 2-3× higher. As a B2B manufacturer, Shaanxi Baisifu Biological Engineering Co., Ltd. supplies Yohimbine HCl in bulk quantities with full Certificate of Analysis (COA), ensuring consistent Yohimbine HCl content and regulatory compliance for dietary supplement, functional food, and nutraceutical applications.
Standard specifications for Yohimbine HCl bulk supply from Baisifu:
Yohimbine is a selective α-2 adrenergic antagonist. α-2 receptors suppress lipolysis when activated ("anti-lipolytic"). By blocking α-2, yohimbine removes this suppression, allowing catecholamines to freely stimulate β-receptors for lipolysis. Particularly effective for "stubborn fat" (lower abs, hips, thighs) where α-2 density is 2-3× higher.
Level II. Increases plasma free fatty acids and norepinephrine, confirming enhanced lipolysis. Galitzky et al. showed 0.2 mg/kg increases resting lipid oxidation by 30%. Must be taken fasted (insulin blocks yohimbine's effect).
âš Significant cardiovascular risk. Increases HR, BP, anxiety. Common: jitteriness, sweating, tachycardia, insomnia. FDA warning letters issued. Not for hypertension, anxiety, heart conditions. Must be taken fasted. Professional supervision recommended.
Shaanxi Baisifu Biological Engineering Co., Ltd. manufactures and supplies Yohimbine HCl (CAS 4142-48-3) in bulk quantities for: • Dietary supplement manufacturers (capsules, softgels, tablets, powders)
• Functional food & beverage producers
• Nutraceutical brands seeking Yohimbine HCl standardized ingredient
• Cosmetics companies (anti-cellulite, metabolic support topical) Each batch includes full Certificate of Analysis (COA) with:
• Yohimbine HCl content verification (HPLC/UV)
• Heavy metals, microbial, moisture compliance
• Pesticide residue testing (where applicable)
• Stability data and shelf life confirmation Available forms: powder extract, oil-based softgel fill, microencapsulated powder
Minimum order: 1 kg (sample quantities available)
Lead time: 7–15 business days
Packaging: 25 kg/drum, double-layer PE bag + fiber drum, nitrogen flush available
Q1: Why must Yohimbine be taken on an empty stomach?
Insulin blocks α-2 receptor antagonism. After eating, insulin suppresses yohimbine's lipolytic effect by up to 90%. Take fasted, 30-60 min before exercise, wait 2-4 hours before eating.
Q2: What makes Yohimbine effective for stubborn fat?
Stubborn fat areas (lower abs, love handles, thighs) have 2-3× higher α-2 receptor density. α-2 suppresses lipolysis there. Yohimbine blocks α-2 specifically, unlocking fat burning in resistant zones.
Q3: Is Yohimbine safe?
5-10 mg/day safe for healthy adults without cardiovascular conditions. Side effects dose-dependent. Never combine with other stimulants. Not for hypertension, heart disease, anxiety.
For complementary weight management formulations, consider combining Yohimbine HCl with: Green Tea Extract, Capsaicin, Forskolin, 6-Paradol. Multi-ingredient stacks targeting different mechanisms (lipase inhibition, AMPK activation, thermogenesis, appetite suppression) produce synergistic effects superior to single-ingredient products.
About Baisifu: Shaanxi Baisifu Biological Engineering Co., Ltd. (No.69, Jinye Road, Xi'an, 710065, Shaanxi, China | Tel: 0086-29-81110978) is a GMP/ISO-certified manufacturer of botanical extracts, food flavors, amino acids, peptides, and biopesticides with 1,000+ products exported to US/EU B2B markets.
Disclaimer: This content is for informational and B2B product development purposes only. Yohimbine HCl (CAS 4142-48-3) is a raw ingredient for dietary supplement and functional food formulation, not a finished consumer product. Claims cited are from published research and regulatory approvals — they do not constitute medical advice or guarantee specific outcomes. Consult regulatory experts for target market compliance.
| Parameter | Specification |
|---|---|
| Yohimbine HCl | 98%+ |
| Appearance | White to off-white crystalline powder |
| Solubility | Highly water-soluble |
| Particle Size | 80 mesh |
| Moisture | ≤2% |
| Heavy Metals | ≤10 ppm |
| Assay | 97-103% |
| pH | 4.0-6.0 |
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