Citrus Aurantium Extract (Synephrine)

Citrus Aurantium Extract (Synephrine) — CAS 94-07-5 | Bulk Supplier & Manufacturer

What is Citrus Aurantium Extract (Synephrine)?

(Citrus Aurantium Extract (Synephrine)) is a botanical extract derived from Citrus aurantium (bitter orange) fruit/peel, standardized to Synephrine. With CAS registry number 94-07-5, this ingredient belongs to the Fat Oxidation & Thermogenesis category of weight management actives. Synephrine stimulates β-3 adrenergic receptors → lipolysis + thermogenesis. Unlike ephedrine (banned 2004), synephrine has minimal β-1/β-2 activity, increasing fat burning without significantly raising heart rate or blood pressure. This selective β-3 mechanism replaced ephedrine as the primary thermogenic agent after the FDA ban. As a B2B manufacturer, Shaanxi Baisifu Biological Engineering Co., Ltd. supplies Citrus Aurantium Extract (Synephrine) in bulk quantities with full Certificate of Analysis (COA), ensuring consistent Synephrine content and regulatory compliance for dietary supplement, functional food, and nutraceutical applications.

Citrus Aurantium Extract (Synephrine) Specifications

Standard specifications for Citrus Aurantium Extract (Synephrine) bulk supply from Baisifu:

How Citrus Aurantium Extract (Synephrine) Works for Weight Loss

Synephrine stimulates β-3 adrenergic receptors → lipolysis + thermogenesis. Unlike ephedrine (banned 2004), synephrine has minimal β-1/β-2 activity, increasing fat burning without significantly raising heart rate or blood pressure. This selective β-3 mechanism replaced ephedrine as the primary thermogenic agent after the FDA ban.

Citrus Aurantium Extract (Synephrine) Clinical Evidence & Research

Level III (controversial). Stohs & Shara (2013) found p-synephrine alone increases metabolic rate without significant cardiovascular effects. However, FDA adverse event reports link Citrus aurantium+caffeine products to elevated BP and rare myocardial infarction. Regulatory scrutiny varies by jurisdiction.

Citrus Aurantium Extract (Synephrine) Applications & Usage

• Weight management capsules (synephrine 6%)
• Fat-burner formulas (often combined with caffeine)
• Pre-workout energy supplements
• Appetite control formulations
• Ephedrine-free thermogenic alternative

Citrus Aurantium Extract (Synephrine) Safety & Regulatory Status

⚠ Moderate cardiovascular risk. FDA warnings for C. aurantium+caffeine combinations. ≤30 mg synephrine/day alone appears safe. Caffeine combination significantly increases BP/HR risk. Restricted/banned in some EU countries.

Citrus Aurantium Extract (Synephrine) — B2B Bulk Supply from Baisifu

Shaanxi Baisifu Biological Engineering Co., Ltd. manufactures and supplies Citrus Aurantium Extract (Synephrine) (CAS 94-07-5) in bulk quantities for: • Dietary supplement manufacturers (capsules, softgels, tablets, powders)
• Functional food & beverage producers
• Nutraceutical brands seeking Synephrine standardized ingredient
• Cosmetics companies (anti-cellulite, metabolic support topical) Each batch includes full Certificate of Analysis (COA) with:
• Synephrine content verification (HPLC/UV)
• Heavy metals, microbial, moisture compliance
• Pesticide residue testing (where applicable)
• Stability data and shelf life confirmation Available forms: powder extract, oil-based softgel fill, microencapsulated powder
Minimum order: 1 kg (sample quantities available)
Lead time: 7–15 business days
Packaging: 25 kg/drum, double-layer PE bag + fiber drum, nitrogen flush available

Citrus Aurantium Extract (Synephrine) — Frequently Asked Questions

Q1: Is Synephrine the same as Ephedrine?

No. Synephrine preferentially activates β-3 (fat burning) with minimal β-1/β-2 (heart rate/BP). Ephedrine activates all β-receptors and was banned by FDA in 2004 for cardiovascular risk.

Q2: What is the safe dosage?

≤30 mg synephrine/day alone. Do not combine with caffeine >150 mg. 6% extract delivers ~6 mg per 100 mg extract.

Q3: Can Synephrine be sold in the EU?

Varies by member state. Some allow ≤30 mg/day (UK, Netherlands), others restrict/ban (France, Germany). Check target market regulations.

Related Weight-Loss Extracts

For complementary weight management formulations, consider combining Citrus Aurantium Extract (Synephrine) with: Green Tea Extract, Capsaicin, 6-Paradol, Forskolin. Multi-ingredient stacks targeting different mechanisms (lipase inhibition, AMPK activation, thermogenesis, appetite suppression) produce synergistic effects superior to single-ingredient products.

About Baisifu: Shaanxi Baisifu Biological Engineering Co., Ltd. (No.69, Jinye Road, Xi'an, 710065, Shaanxi, China | Tel: 0086-29-81110978) is a GMP/ISO-certified manufacturer of botanical extracts, food flavors, amino acids, peptides, and biopesticides with 1,000+ products exported to US/EU B2B markets.

Disclaimer: This content is for informational and B2B product development purposes only. Citrus Aurantium Extract (Synephrine) (CAS 94-07-5) is a raw ingredient for dietary supplement and functional food formulation, not a finished consumer product. Claims cited are from published research and regulatory approvals — they do not constitute medical advice or guarantee specific outcomes. Consult regulatory experts for target market compliance.