029-81163280
13519147002
Purity: 99%
Place of Origin: Shaanxi, China
Brand Name: BAISFU
Type: Plant extract
Form: Powder
Product Name:Cyclopamin
Storage: Dark seal, should be stored in a cool, dry, ventilated warehouse
Purity: 99%
Shelf Life: 2 years
Original: Shaanxi, China
MOQ: 5 kg
Selling Units: Single item
Single package size: 55.6X32.75X27.05 cm
Single gross weight: 2.000 kg
Continuous Supply of Cyclopamine for Anti-Tumor and Biopharmaceutical Plants
Cyclopamine is an isosteroidal alkaloid isolated from the genus veratrum, It is found mainly in the North American mountain Veratrum californicum, Indian deer herbivore (Cornlily), hairy leaf Veratrum grandiflorum and Ibe (Fritillaria pallidiflora) Schrenk) and other plants . The chemical properties of cyclopamine include a melting point of 236-238°C, a boiling point of 531.29°C (rough estimate), a density of 1.0274 (rough estimate), a acidity factor (pKa) of 15.05±0.70 (forecast), a white solid appearance, and storage conditions at -20°C in a dark and inert atmosphere .
Chemical structure
The molecular formula of cyclopamine is C27H41NO2 and the molecular weight is 411.62. It is a complex hexacyclic natural product with a C-nor-D-homo steroid skeleton and a fully substituted tetrahydrofuran E ring connected by a helix form, a unique trans-6,5-EF ring, and an intermediate D ring containing a tetrasubstituted alkene structural feature .
Biological activity
Cyclopamine is a potent inhibitor of Hedgehog signaling pathway, which can interfere with the correct differentiation and symmetrical development of embryos, and has significant antitumor activity. It has shown inhibitory effects in a variety of tumor models, including malignant tumors such as basal cell tumor, glioma, small cell lung cancer, stomach cancer, and breast cancer . In addition, cyclopamine has been proven to have anti-tumor effects in vivo or in vitro in pancreatic cancer, bile duct cancer, ovarian cancer, liver cancer, etc .
Synthesis method
The synthesis of cyclopamine is challenging, and its complete synthesis was recently achieved by Phil S. Baran of the Scripps Research Institute in the United States. The synthetic route consists of converging enantioselective total synthesis involving several key steps such as cyclization, alkylation, CuH reduction, asymmetric allyl alkylation, aza-Michael addition, halogenation, Tsuji−Trost cyclization and RCM reaction .
Application field
Cyclopamine has potential application value in the field of medicine and can be used as the lead substance of anti-tumor drugs. In addition, cyclopamine can also be used as a marker for antibody preparation and immune detection, for example, as a tool for signal amplification and visualization in ELISA and other experiments .
Continuous Supply of Cyclopamine for Anti-Tumor and Biopharmaceutical Plants
Applications of Cyclopamine include anti-tumor research and treatment, biomedical research, and chemical and biological science research.
Anti-tumor research and treatment
Cyclopamine has significant inhibitory effects on a variety of tumors, including medulloblastoma, basal cell carcinoma, glioma, rhabdomyosarcoma, small cell lung cancer, digestive tract tumors (such as gastric cancer), breast cancer, pancreatic cancer, and prostate cancer . In antitumor studies, cyclopamine acts by inhibiting Hedgehog signaling pathway, which is associated with mutation-related response pathways in the proto-oncogene Smoothened (Smo) or inactivated tumor suppressor gene Patched (Ptch) . Studies have shown that cyclopamine can effectively shrink pancreatic and stomach tumors and has shown anti-tumor effects in vitro experiments in mice and human cells .
Biomedical research
Cyclopamine is also widely used in biomedical research. For example, cyclopamine can be used to study cell development profiles, revealing its mechanism of action in cancer metastasis. Cyclopamine was found to promote metastasis by activating non-cellular autonomic effects of the Hh pathway, suggesting that it has important implications in understanding the mechanisms of cancer metastasis . In addition, cyclopamine has been used to investigate the role of EMT (epithelial-mesenchymal transition) in cancer metastasis, and it has been found that EMT cells induce increased metastasis of non-EMT cells by paracrine means, in part due to non-cellular autonomic activation of GLI transcription factors .
Chemical and biological science research
Cyclopamine, as an isosteroid alkaloid, is isolated from the genus veratrum and mainly exists in the plants of North American mountain veratrum, Indian deer herbivore, hairy leaf veratrum and Ibe . It also has important applications in chemical and biological science research, such as for studying the activation and inhibition mechanisms of the Hedgehog signaling pathway.
To sum up, cyclopamine has been widely used in anti-tumor research, biomedicine, chemical and biological sciences, and its unique pharmacological effects make it an important research tool in these fields.
Shaanxi Baisfu Bioengineering Co., Ltd. is an enterprise specializing in the research and development, production and sales of flavors and fragrances. The company is located in Building A, Baodeyun Valley, No. 52, Jinye 1st Road, Yanta District, Xi'an City, Shaanxi Province. It has an excellent geographical location and convenient transportation. convenient. The company was established in December 2019, with a registered capital of 3 million yuan.
The company's main products include cooling agents, synthetic flavors and natural flavors. The company's products can be used in food and beverage, daily chemical, and other industries, and have a wide range of downstream applications.
The company always attaches great importance to product quality and brand reputation, strictly implements product quality and environmental management control, and has passed various certifications such as GPM, ISO9001, ISO14001, kosher, and HALAL European analysis.
The company's products are used by more than 30 foreign companies and regions. After more than ten years of technology accumulation and market development, the company has accumulated a group of high-quality customer groups, stable customer channels and resources, and has established relationships with more than 100 domestic and foreign companies. Good working relations.
Continuous Supply of Cyclopamine for Anti-Tumor and Biopharmaceutical Plants
Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers' requirement.
Storage: Store in cool & dry place. Keep away from strong light and heat.
Delivery: 1-2 working days after payment/FedEx, DHL, TNT, EMS, etc.
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A: Please provide the exact or approximate quantity, packing details, destination port or special requirements, then we could give you the price accordingly.
Q2: What is your terms of payment?
A: TT Transfer, CAD, L/C, All is available.
Q3: How can I get a sample?
A: We can provide free samples for your test.
Q4: Do you have MOQ ?
A: Yes, but low MOQ for sample checking is available.
Q5: How do you garantee the quality?
A: First of all, our quality control will reduce the quality problem to near zero. When the production is finished, they'll take samples from every batch of cargo, and send to our lab for inspection. After passed the inspection, then we will arrange the delivery.
Q6: How about your after-sale service ?
A: If any technical or quality problem after you receive the cargo, you can contact us any time. If the problem caused by us, we will send you free goods for replacement or refund your loss.